Clay Jonathan, an artist who was originally diagnosed with depression in 1993, depicts his experience with the illness through his website Depression Comix. In this drawing, Clay uses a man holding a missing person poster with an image of himself when he was happy, expressing the difficulties that an individual with depression experiences when attempting to find happiness once more.

Image Credit
Feature: DpressedSoul at DeviantArt, Creative Commons
Body: Clay Jonathan at Depression Comix